Water yield is a key indicator of the performance and valuable service of the ecosystem that directly affects the sustainable development of the economy, human well-being, and ecosystems of a basin. Using the Integrated Valuation of Ecosystem Services and Tradeoffs model (InVEST), water yield changes were simulated in 10 basins by the eastern BORDER in South Khorasan province under the influence of land use/land cover changes. The model was calibrated using the long-term data of flow at Efin, Khonik Olia, Mansourabad, Gezik, and Ahangaran stations. Also, the economic value of water yield service was calculated in each of the different land uses/land covers. The results showed the highest and the lowest volume of produced water respectively in Esfadan basin with 8,126,129 cubic meters and in Namakzar-Khaf Basin with 185,590 cubic meters. The amount of water yield in the whole studied area was 14,836,168 cubic meters. In terms of the land use/land cover, the highest amount of water yield was obtained in lands with dense and semi-dense range with more than 12,430,000 cubic meters followed by the lands with sparse range with more than 1,990,000 cubic meters. The total economic value of the water yield in the eastern BORDER basins was equal to 16,115,806.5 million Rials. The spatial distribution of economic values of the ecosystem, which was carried out in this research through quantification, mapping and valuation, of ecosystem services, can be used as an important and reliable tool for natural capital management and policy making.